PEA15
Sign in to saveAlso known as HMAT1, HUMMAT1H, MAT1, MAT1H, PEA-15, PED, phosphoprotein enriched in astrocytes 15, PED-PEA15
Astrocytic phosphoprotein PEA-15 is a protein that in humans is encoded by the PEA15 gene.
Gene data
PEA15- Name
- proliferation and apoptosis adaptor protein 15
- Type
- protein-coding
- Position
- 160,205,328–160,220,335 (+)
- Aliases
- HMAT1, HUMMAT1H, MAT1, MAT1H, PEA-15, PED, PED-PEA15, PED/PEA15
- Ensembl
- ENSG00000162734
- RefSeq RNA
- NM_001297576.2, NM_001297577.2, NM_001297578.2, NM_003768.5, NR_123724.2
- RefSeq protein
- NP_001284505.1, NP_001284506.1, NP_001284507.1, NP_003759.1, XP_047289347.1
This gene encodes a death effector domain-containing protein that functions as a negative regulator of apoptosis. The encoded protein is an endogenous substrate for protein kinase C. This protein is also overexpressed in type 2 diabetes mellitus, where it may contribute to insulin resistance in glucose uptake. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
proliferation and apoptosis adaptor protein 15
- Symbol
- PEA15
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:160,205,328-160,220,335
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein PEA15 PDB 1n3k.png
Show 7 more facts
- HomoloGene ID
- 7884
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/8682
- genomic start
- 160205380
- chromosome
- human chromosome 1
- genomic end
- 160185166
- cytogenetic location
- 1q23.2
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Interactions
- References
- Further reading
Astrocytic phosphoprotein PEA-15 is a protein that in humans is encoded by the PEA15 gene.
PEA15 is a death effector domain (DED)-containing protein predominantly expressed in the central nervous system, particularly in astrocytes.
Excerpted from Wikipedia’s “PEA15” article, available under the CC BY-SA 4.0 licence.