FADD
Sign in to saveFAS-associated death domain protein, also called MORT1, is encoded by the FADD gene on the 11q13.3 region of chromosome 11 in humans.
Article
23 sectionsContents
- Structure
- Functions
- Extrinsic apoptosis
- Necroptosis
- Autophagic cell death
- Development
- Cell cycle regulation
- Lymphocyte proliferation
- Inflammation
- Other
- Regulation
- Subcellular localisation
- c-FLIP
- PKC
- MKRN1
- Roles in inflammatory diseases
- Roles in cancer
- Therapeutic target
- Interactions
- See also
- References
- Further reading
- External links
FAS-associated death domain protein, also called MORT1, is encoded by the FADD gene on the 11q13.3 region of chromosome 11 in humans.
FADD is an adaptor protein that bridges members of the tumor necrosis factor receptor superfamily, such as the Fas-receptor, to procaspases 8 and 10 to form the death-inducing signaling complex (DISC) during apoptosis. As well as its most well known role in apoptosis, FADD has also been seen to play a role in other processes including proliferation, cell cycle regulation and development.