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GeneQ14887700· pop 8· linked from 53 articles

PIK3CA

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Also known as CLOVE, CWS5, MCAP, MCM, MCMTC, PI3K, p110-alpha, PI3K-alpha

The phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (the HUGO-approved official symbol = PIK3CA; HGNC ID, HGNC:8975), also called p110α protein, is a class I PI 3-kinase catalytic subunit. The human p110α protein is encoded by the PIK3CA gene.

Gene data

PIK3CA
Name
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
Type
protein-coding
Position
179,148,114–179,240,093 (+)
Aliases
CCM4, CLAPO, CLOVE, CWS5, HMH, MCAP, MCM, MCMTC, PI3K, PI3K-alpha
Ensembl
ENSG00000121879
RefSeq RNA
NM_006218.4, XM_006713658.5, XM_054346842.1, XM_054346843.1, XM_054346844.1
RefSeq protein
NP_006209.2, XP_006713721.1, XP_054202817.1, XP_054202818.1, XP_054202819.1

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers. A pseudogene of this gene has been defined on chromosome 22. [provided by RefSeq, Apr 2016].

Gene Ontology

Pathways

Inositol phosphate metabolism - Homo sapiens (human)ErbB signaling pathway - Homo sapiens (human)Ras signaling pathway - Homo sapiens (human)Rap1 signaling pathway - Homo sapiens (human)cAMP signaling pathway - Homo sapiens (human)Chemokine signaling pathway - Homo sapiens (human)HIF-1 signaling pathway - Homo sapiens (human)FoxO signaling pathway - Homo sapiens (human)Phosphatidylinositol signaling system - Homo sapiens (human)Sphingolipid signaling pathway - Homo sapiens (human)

via MyGene.info

Gene · Ensembl

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

Symbol
PIK3CA
Biotype
Protein coding
Organism
Homo sapiens
Location
3:179,148,114-179,240,093
Strand
Forward (+)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

~3 min read

Encyclopedic overview

8 sections
Contents
  • Function
  • Clinical characteristics
  • Inhibition
  • Pharmacology
  • See also
  • Interactions
  • References
  • Further reading

The phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (the HUGO-approved official symbol = PIK3CA; HGNC ID, HGNC:8975), also called p110α protein, is a class I PI 3-kinase catalytic subunit. The human p110α protein is encoded by the PIK3CA gene.

Its role was uncovered by molecular pathological epidemiology (MPE).

Excerpted from Wikipedia’s “PIK3CA” article, available under the CC BY-SA 4.0 licence.

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