ARHGEF1

Also known as GEF1, LBCL2, LSC, P115-RHOGEF, SUB1.5, Rho guanine nucleotide exchange factor 1, IMD62

Rho guanine nucleotide exchange factor 1 is a protein that in humans is encoded by the ARHGEF1 gene. This protein is also called RhoGEF1 or p115-RhoGEF.

Gene data

ARHGEF1

Name: Rho guanine nucleotide exchange factor 1
Type: protein-coding
Position: 41,883,063–41,930,150 (+)
Aliases: GEF1, IMD62, LBCL2, LSC, P115-RHOGEF, SUB1.5
Ensembl: ENSG00000076928
RefSeq RNA: NM_001396000.1, NM_001396002.1, NM_001396003.1, NM_001396004.1, NM_001396006.1
RefSeq protein: NP_001382929.1, NP_001382931.1, NP_001382932.1, NP_001382933.1, NP_001382935.1

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2008].

Pathways

via MyGene.info

Gene · Ensembl

Rho guanine nucleotide exchange factor 1

Symbol: ARHGEF1
Biotype: Protein coding
Organism: Homo sapiens
Location: 19:41,883,063-41,930,150
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

~2 min read

Encyclopedic overview

6 sections

Contents

Function
Interactions
See also
References
External links
Further reading

Rho guanine nucleotide exchange factor 1 is a protein that in humans is encoded by the ARHGEF1 gene. This protein is also called RhoGEF1 or p115-RhoGEF.

== Function == Rho guanine nucleotide exchange factor 1 is guanine nucleotide exchange factor (GEF) for the RhoA small GTPase protein. Rho is a small GTPase protein that is inactive when bound to the guanine nucleotide GDP. But when acted on by Rho GEF proteins such as RhoGEF1, this GDP is released and replaced by GTP, leading to the active state of Rho. In this active, GTP-bound conformation, Rho can bind to and activate specific effector proteins and enzymes to regulate cellular functions. In particular, active Rho is a major regulator of the cell actin cytoskeleton.

Excerpted from Wikipedia’s “ARHGEF1” article, available under the CC BY-SA 4.0 licence.