PILRA
Sign in to saveAlso known as FDF03, paired immunoglobin like type 2 receptor alpha
Paired immunoglobin like type 2 receptor alpha is a protein that in humans is encoded by the PILRA gene.
Gene data
PILRA- Name
- paired immunoglobin like type 2 receptor alpha
- Type
- protein-coding
- Aliases
- FDF03
Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, are described. [provided by RefSeq, Jul 2008].
via MyGene.info
Gene · Ensembl
paired immunoglobin like type 2 receptor alpha
- Symbol
- PILRA
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 7:100,367,530-100,400,098
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- 4nfb red PILRA 4nfc yellow PILRB.png
Show 8 more facts
- HomoloGene ID
- 8387
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/29992
- genomic end
- 100400096
- genomic start
- 99965153
- chromosome
- human chromosome 7
- cytogenetic location
- 7q22.1
- expressed in
- appendix
Sources (4)
via Wikidata · CC0
~2 min read
Encyclopedic overview
4 sectionsContents
- Function
- Structure
- References
- Further reading
Paired immunoglobin like type 2 receptor alpha is a protein that in humans is encoded by the PILRA gene.
== Function == Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts.
Excerpted from Wikipedia’s “PILRA” article, available under the CC BY-SA 4.0 licence.