PILRB
Sign in to saveAlso known as FDFACT1, FDFACT2, paired immunoglobin-like type 2 receptor beta, paired immunoglobin like type 2 receptor beta
Paired immunoglobulin-like type 2 receptor beta is a protein that in humans is encoded by the PILRB gene.
Gene data
PILRB- Name
- paired immunoglobin like type 2 receptor beta
- Type
- protein-coding
- Position
- 100,351,627–100,367,831 (+)
- Aliases
- FDFACT1, FDFACT2
- Ensembl
- ENSG00000121716
- RefSeq RNA
- NM_001371931.2, NM_013440.3, NM_175047.2, NM_178238.4
- RefSeq protein
- NP_001358860.1, NP_839956.1
The paired immunoglobin-like type 2 receptors consist of highly related activating and inhibitory receptors that are involved in the regulation of many aspects of the immune system. The paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This gene encodes the activating member of the receptor pair and contains a truncated cytoplasmic tail relative to its inhibitory counterpart (PILRA), that has a long cytoplasmic tail with immunoreceptor tyrosine-based inhibitory (ITIM) motifs. This gene is thought to have arisen from a duplication of the inhibitory PILRA gene and evolved to acquire its activating function. [provided by RefSeq, Jun 2013].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
paired immunoglobin like type 2 receptor beta
- Symbol
- PILRB
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 7:100,351,627-100,367,831
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- 4nfb red PILRA 4nfc yellow PILRB.png
Show 8 more facts
- HomoloGene ID
- 114502
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/29990
- genomic end
- 100367831
- genomic start
- 99933737
- chromosome
- human chromosome 7
- cytogenetic location
- 7q22.1
- expressed in
- spleen
Sources (4)
via Wikidata · CC0
~2 min read
Encyclopedic overview
3 sectionsContents
- Function
- Structure
- References
Paired immunoglobulin-like type 2 receptor beta is a protein that in humans is encoded by the PILRB gene.
== Function == Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts.
Excerpted from Wikipedia’s “PILRB” article, available under the CC BY-SA 4.0 licence.