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GeneQ18030578· pop 6· linked from 6 articles

PLAGL1

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Also known as LOT1, ZAC, ZAC1, PLAG1 like zinc finger 1

Zinc finger protein PLAGL1 is a protein that in humans is encoded by the PLAGL1 gene.

Gene data

PLAGL1

Name: PLAG1 like zinc finger 1
Type: protein-coding
Position: 143,940,300–144,064,714 (−)
Aliases: LOT1, ZAC, ZAC1
Ensembl: ENSG00000118495
RefSeq RNA: NM_001080951.3, NM_001080952.3, NM_001080953.3, NM_001080954.3, NM_001080955.3
RefSeq protein: NP_001074420.1, NP_001074421.1, NP_001074422.1, NP_001074423.1, NP_001074424.1

This gene encodes a C2H2 zinc finger protein that functions as a suppressor of cell growth. This gene is often deleted or methylated and silenced in cancer cells. In addition, overexpression of this gene during fetal development is thought to be the causal factor for transient neonatal diabetes mellitus (TNDM). Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding two different protein isoforms. The P1 downstream promoter of this gene is imprinted, with preferential expression from the paternal allele in many tissues. [provided by RefSeq, Nov 2015].

Gene Ontology

Biological process

negative regulation of transcription by RNA polymerase II regulation of cytokine production regulation of immune system process apoptotic process positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II regulation of cell cycle

Molecular function

RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA binding

Cellular component

nucleus nucleoplasm nucleoplasm nuclear body nuclear body

Pathways

Generic Transcription Pathway Transcriptional Regulation by TP53 TP53 Regulates Transcription of Cell Cycle Genes TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain RNA Polymerase II Transcription Gene expression (Transcription)Aryl Hydrocarbon Receptor Netpath

via MyGene.info

Gene · Ensembl

PLAG1 like zinc finger 1

Symbol: PLAGL1
Biotype: Protein coding
Organism: Homo sapiens
Location: 6:143,940,300-144,064,714
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

~1 min read

Encyclopedic overview

4 sections

Contents

Function
Interactions
References
Further reading

Zinc finger protein PLAGL1 is a protein that in humans is encoded by the PLAGL1 gene.

== Function ==

Excerpted from Wikipedia’s “PLAGL1” article, available under the CC BY-SA 4.0 licence.

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