PLEK
Sign in to saveAlso known as Pleckstrin, pleckstrin, P47
Pleckstrins are a family of proteins found in platelets and other cells. The name derives from platelet and leukocyte C kinase substrate and the KSTR string of amino acids. The prototype protein, now called pleckstrin-1, was first identified in 1979 as the major substrate of protein kinase C in platelets. The homolog pleckstrin-2 is more widely expressed in tissues.
Gene data
PLEK- Name
- pleckstrin
- Type
- protein-coding
- Position
- 68,365,075–68,397,453 (+)
- Aliases
- P47, PLEK1
- Ensembl
- ENSG00000115956
- RefSeq RNA
- NM_002664.3, XM_047444772.1, XM_054342575.1, XM_054342576.1
- RefSeq protein
- NP_002655.2, XP_047300728.1, XP_054198550.1, XP_054198551.1
Enables phosphatidylinositol-3,4-bisphosphate binding activity; protein homodimerization activity; and protein kinase C binding activity. Involved in several processes, including G protein-coupled receptor signaling pathway; actin cytoskeleton organization; and positive regulation of supramolecular fiber organization. Located in cytoplasm and ruffle membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
pleckstrin
- Symbol
- PLEK
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 2:68,365,075-68,397,453
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 10 more facts
- Commons category
- Pleckstrin
- HomoloGene ID
- 2000
- genetic association
- celiac disease
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/5341
- genomic end
- 68624585
- genomic start
- 68365282
- chromosome
- human chromosome 2
- cytogenetic location
- 2p14
- expressed in
- trabecular bone
via Wikidata · CC0
~3 min read
Encyclopedic overview
4 sectionsContents
- Sequence and structure
- Functions
- References
- External links
Pleckstrins are a family of proteins found in platelets and other cells. The name derives from platelet and leukocyte C kinase substrate and the KSTR string of amino acids. The prototype protein, now called pleckstrin-1, was first identified in 1979 as the major substrate of protein kinase C in platelets. The homolog pleckstrin-2 is more widely expressed in tissues.
The pleckstrin homology domain (PH domain) was named after pleckstrin-1.
Excerpted from Wikipedia’s “PLEK” article, available under the CC BY-SA 4.0 licence.