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celiac disease

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celiac disease

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Also known as nontropical sprue, endemic sprue, gluten enteropathy, idiopathic steatorrhea, CeD, coeliac disease, celiac sprue

long term autoimmune disorder caused by a reaction to gluten

OverviewAI-generated

Celiac disease, also referred to as coeliac disease, is a medical condition classified under the ICD-9-CM code 579.0. It is identified in the ICPC 2 system with the code D99 and is associated with the NCI Thesaurus ID C26714. The condition is further cataloged in the Orphanet database and the Human Phenotype Ontology.

Information regarding the disease is available through various health resources, including the NHS and NICE guidance documents. The subject is referenced by 1,001 other encyclopedia articles. A search for celiac disease in PubMed yields 32,912 results.

Synthesized by Vinony from 13 facts across 4 sources: Wikidata, Firecrawl, PubMed, Vinony graph. Generated from structured data (not the Wikipedia text) and checked against those facts — may still contain errors.

Research

32,912 papers

via PubMed

Described at

Coeliac disease - NHS

Find out about coeliac disease, an autoimmune disease affecting the digestive system that makes a person have an adverse reaction to gluten.

nhs.uk

Your choice will be remembered for other online NHS services, such as the NHS App. Coeliac disease is a condition where your immune system attacks your own tissues when you eat gluten. This damages your gut (small intestine) so your body cannot properly take in nutrients. Coeliac disease can cause a range of symptoms, including diarrhoea, abdominal pain and bloating. Children with coeliac disease may not grow at the expected rate and may have delayed puberty . Coeliac disease is an autoimmune condition. This is where the immune system (the body's defence against infection) mistakenly attacks healthy tissue. In coeliac disease, the immune system mistakes substances found inside gluten as a threat to the body and attacks them. This damages the surface of the small bowel (intestines), disrupting the body's ability to take in nutrients from food. It's not entirely clear what causes the immune system to act this way, but a combination of genetics and the environment appear to play a part. There's no cure for coeliac disease, but following a gluten-free diet should help control symptoms and prevent the long-term complications of the condition. Even if you have mild symptoms, changing your diet is still recommended because continuing to eat gluten can lead to serious complications. This may also be the case if tests show that you have some degree of coeliac disease even if you do not have noticeable symptoms. It's important to ensure that your gluten-free diet is healthy and balanced. Complications of coeliac disease only tend to affect people who continue to eat gluten, or those who have not yet been diagnosed with the condition, which can be a common problem in milder cases. Less common and more serious complications include some types of cancers, such as bowel cancer , and problems affecting pregnancy, such as your baby having a low birth weight. But some experts think this may be underestimated because milder cases may go undiagnosed or be misdiagnosed as other digestive conditions, such as irritable bowel syndrome (IBS) . People with certain conditions, including type 1 diabetes , autoimmune thyroid disease, Down's syndrome and Turner syndrome , have an increased risk of getting coeliac disease. First-degree relatives (parents, brothers, sisters and children) of people with coeliac disease are also at increased risk of developing the condition. Testing is usually only recommended for people who have symptoms, or who have an increased risk of developing coeliac disease, such as those with a family history of the condition. Read about diagnosing coeliac disease for more information about when testing for coeliac disease should be done. Its website has useful resources, including information about a gluten-free diet, local groups, volunteering and ongoing campaigns.

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Encyclopedic overview

Coeliac disease (Commonwealth English) or celiac disease (American English) is a chronic autoimmune disease, mainly affecting the small intestine. It is caused by an abnormal immune system response to gluten, a protein found in wheat and other grains such as barley and rye. Coeliac disease causes a wide range of symptoms and complications that can affect multiple organs outside the gastrointestinal tract.

The classic form of the disease can affect any age group, but is usually diagnosed in early childhood and causes symptoms of malabsorption such as weight loss, diarrhoea, and stunted growth. Non-classic coeliac disease is more commonly seen in adults, characterised by vague abdominal symptoms and complications in organs outside the gastrointestinal tract, such as bone disease, anaemia, and other consequences of nutritional deficiencies. In people with a genetic predisposition to the condition, eating gluten causes inflammation in the small intestine, damaging its lining and leading to malabsorption. The development of coeliac disease is believed to be influenced by other environmental factors, such as infections.

Excerpted from Wikipedia’s “celiac disease” article, available under the CC BY-SA 4.0 licence.

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