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Podokaliksyna

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Podocalyxin, a sialoglycoprotein, is thought to be the major constituent of the glycocalyx of podocytes in the glomerulus (Bowman's capsule) in the kidneys. It is a member of the CD34 family of transmembrane sialomucins. It coats the secondary foot processes of the podocytes. It is negatively charged and thus functions through charge repulsion to keep adjacent foot processes separated, thereby keeping the urinary filtration barrier open. This function is further supported by knockout studies in mice which reveal an essential role in podocyte morphogenesis and a role in the opening of vascular

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protein
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Article · Polski

Podokaliksyna – rodzaj , wchodzącej w skład glikokaliksu pokrywającego podocyty. Należy do rodziny białek transbłonowych CD35. Jest silnym polianionem, dzięki czemu nadaje elektryczny ładunek ujemny części luminalnej wypustki stopowatej podocytu i sprawia, że cząsteczki o ładunku ujemnym, np. albuminy, nie są przepuszczalne przez .

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