Podocalixina
Sign in to savePodocalyxin, a sialoglycoprotein, is thought to be the major constituent of the glycocalyx of podocytes in the glomerulus (Bowman's capsule) in the kidneys. It is a member of the CD34 family of transmembrane sialomucins. It coats the secondary foot processes of the podocytes. It is negatively charged and thus functions through charge repulsion to keep adjacent foot processes separated, thereby keeping the urinary filtration barrier open. This function is further supported by knockout studies in mice which reveal an essential role in podocyte morphogenesis and a role in the opening of vascular
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It is catalogued under topics including Protein pages needing a picture and Single-pass transmembrane proteins.
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Article · Italiano
La Podocalixina, una , è probabilmente il principale costituente del glicocalice dei podociti e ricopre i pedicelli di queste cellule. Ha una carica elettrica negativa e, quindi, mantiene separati i pedicelli adiacenti, permettendo che la barriera di filtrazione del glomerulo rimanga aperta.
Abstract from DBpedia / Wikipedia · CC BY-SA