PPFIBP1
Sign in to saveAlso known as L2, SGT2, hSGT2, hSgt2p, PPFIA binding protein 1
Liprin-beta-1 is a protein that in humans is encoded by the PPFIBP1 gene.
Gene data
PPFIBP1- Name
- PPFIB scaffold protein 1
- Type
- protein-coding
- Position
- 27,523,431–27,696,302 (+)
- Aliases
- L2, NEDSMBA, SGT2, hSGT2, hSgt2p
- Ensembl
- ENSG00000110841
- RefSeq RNA
- NM_001198915.2, NM_001198916.2, NM_003622.4, NM_177444.3, XM_006719159.5
- RefSeq protein
- NP_001185844.1, NP_001185845.2, NP_003613.4, NP_803193.3, XP_006719222.1
The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. It has been proposed that liprins are multivalent proteins that form complex structures and act as scaffolds for the recruitment and anchoring of LAR family of tyrosine phosphatases. This protein was found to interact with S100A4, a calcium-binding protein related to tumor invasiveness and metastasis. In vitro experiment demonstrated that the interaction inhibited the phosphorylation of this protein by protein kinase C and protein kinase CK2. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
PPFIB scaffold protein 1
- Symbol
- PPFIBP1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 12:27,523,431-27,696,302
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 2685
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/8496
- genomic end
- 27848497
- genomic start
- 27676364
- expressed in
- right ventricle
- chromosome
- human chromosome 12
- cytogenetic location
- 12p11.23-p11.22
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Interactions
- References
- Further reading
Liprin-beta-1 is a protein that in humans is encoded by the PPFIBP1 gene.
The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. It has been proposed that liprins are multivalent proteins that form complex structures and act as scaffolds for the recruitment and anchoring of LAR family of tyrosine phosphatases. This protein was found to interact with S100A4, a calcium-binding protein related to tumor invasiveness and metastasis. In vitro experiment demonstrated that the interaction inhibited the phosphorylation of this protein by protein kinase C and protein kinase CK2. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
Excerpted from Wikipedia’s “PPFIBP1” article, available under the CC BY-SA 4.0 licence.