PPFIA1

Name

PPFI scaffold protein A1

Type

protein-coding

Position

70,270,655–70,385,312 (+)

Aliases

LIP.1, LIP1, LIPRIN

Ensembl

ENSG00000288198

RefSeq RNA

NM_001378006.1, NM_003626.5, NM_177423.3, NR_045286.3, XM_006718716.4

RefSeq protein

NP_001364935.1, NP_003617.1, NP_803172.1, XP_006718779.1, XP_011543608.1

The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. This protein binds to the intracellular membrane-distal phosphatase domain of tyrosine phosphatase LAR, and appears to localize LAR to cell focal adhesions. This interaction may regulate the disassembly of focal adhesion and thus help orchestrate cell-matrix interactions. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

PPFI scaffold protein A1

Symbol

PPFIA1

Biotype

Protein coding

Organism

Homo sapiens

Location

11:70,270,655-70,385,312

Strand

Forward (+)

Assembly

GRCh38

Wikidata facts

Instance of

gene

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