PPP1R12A
Sign in to saveAlso known as M130, MBS, MYPT1, protein phosphatase 1 regulatory subunit 12A, GUBS
Protein phosphatase 1 regulatory subunit 12A is an enzyme that in humans is encoded by the PPP1R12A gene.
Gene data
PPP1R12A- Name
- protein phosphatase 1 regulatory subunit 12A
- Type
- protein-coding
- Position
- 79,772,140–79,935,460 (−)
- Aliases
- GUBS, M130, MBS, MYPT1
- Ensembl
- ENSG00000058272
- RefSeq RNA
- NM_001143885.2, NM_001143886.2, NM_001244990.2, NM_001244992.1, NM_002480.3
- RefSeq protein
- NP_001137357.1, NP_001137358.1, NP_001231919.1, NP_001231921.1, NP_002471.1
Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC. Thus, Rho appears to inhibit myosin phosphatase through the action of Rho-kinase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
protein phosphatase 1 regulatory subunit 12A
- Symbol
- PPP1R12A
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 12:79,772,140-79,935,460
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein PPP1R12A PDB 1s70.png
Show 8 more facts
- HomoloGene ID
- 1855
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/4659
- genomic end
- 80329240
- genomic start
- 80167343
- chromosome
- human chromosome 12
- cytogenetic location
- 12q21.2-q21.31
- expressed in
- vena cava
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
4 sectionsContents
- Interactions
- References
- Further reading
- External links
Protein phosphatase 1 regulatory subunit 12A is an enzyme that in humans is encoded by the PPP1R12A gene.
Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC. Thus, Rho appears to inhibit myosin phosphatase through the action of Rho-kinase.
Excerpted from Wikipedia’s “PPP1R12A” article, available under the CC BY-SA 4.0 licence.