IL16

Name

interleukin 16

Type

protein-coding

Position

81,159,575–81,314,058 (+)

Aliases

LCF, NIL16, PRIL16, prIL-16

Ensembl

ENSG00000172349

RefSeq RNA

NM_001172128.2, NM_001352684.2, NM_001352685.2, NM_001352686.2, NM_001438661.1

RefSeq protein

NP_001165599.1, NP_001339613.1, NP_001339614.1, NP_001339615.1, NP_001425590.1

The protein encoded by this gene is a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication. The signaling process of this cytokine is mediated by CD4. The product of this gene undergoes proteolytic processing, which is found to yield two functional proteins. The cytokine function is exclusively attributed to the secreted C-terminal peptide, while the N-terminal product may play a role in cell cycle control. Caspase 3 is reported to be involved in the proteolytic processing of this protein. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010].

via MyGene.info

Gene · Ensembl

interleukin 16

Symbol

IL16

Biotype

Protein coding

Organism

Homo sapiens

Location

15:81,159,575-81,314,058

Strand

Forward (+)

Assembly

GRCh38