PPRC1

Also known as PRC, peroxisome proliferator-activated receptor gamma, coactivator-related 1, PPARG related coactivator 1

Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 is a protein that in humans is encoded by the PPRC1 gene.

In the Vinony graph

Within Vinony's link graph, PPRC1 is referenced by 4 other articles, and connects out to PubMed, human chromosome 10 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 10.

Its subject is documented across 5 Wikipedia language editions.

Gene data

PPRC1

Name: PPARG related coactivator 1
Type: protein-coding
Position: 102,132,994–102,150,333 (+)
Aliases: PRC
Ensembl: ENSG00000148840
RefSeq RNA: NM_001288727.2, NM_001288728.2, NM_015062.5, XM_006717731.4, XM_011539549.3
RefSeq protein: NP_001275656.1, NP_001275657.1, NP_055877.3, XP_006717794.1, XP_011537851.1

The protein encoded by this gene is similar to PPAR-gamma coactivator 1 (PPARGC1/PGC-1), a protein that can activate mitochondrial biogenesis in part through a direct interaction with nuclear respiratory factor 1 (NRF1). This protein has been shown to interact with NRF1. It is thought to be a functional relative of PPAR-gamma coactivator 1 that activates mitochondrial biogenesis through NRF1 in response to proliferative signals. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013].

Gene Ontology

Biological process

positive regulation of transcription by RNA polymerase II energy homeostasis

Molecular function

nucleic acid binding transcription coregulator activity transcription coactivator activity RNA binding RNA binding

Cellular component

nucleus nucleus nucleoplasm nucleoplasm

Pathways

Mitochondrial biogenesis Organelle biogenesis and maintenance Transcriptional activation of mitochondrial biogenesis Energy Metabolism Mitochondrial Gene Expression

via MyGene.info

Gene · Ensembl

PPARG related coactivator 1

Symbol: PPRC1
Biotype: Protein coding
Organism: Homo sapiens
Location: 10:102,132,994-102,150,333
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 8 more facts

HomoloGene ID: 9006
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/23082
genomic end: 102150333
genomic start: 103892787
chromosome: human chromosome 10
cytogenetic location: 10q24.32
expressed in: gonad

Sources (4)

via Wikidata · CC0

~1 min read

Encyclopedic overview

3 sections

Contents

Interactions
References
Further reading

Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 is a protein that in humans is encoded by the PPRC1 gene.

The protein encoded by this gene is similar to PPAR-gamma coactivator 1 (PPARGC1/PGC-1), a protein that can activate mitochondrial biogenesis in part through a direct interaction with nuclear respiratory factor 1 (NRF1). This protein has been shown to interact with NRF1. It is thought to be a functional relative of PPARGC1 that activates mitochondrial biogenesis through NRF1 in response to proliferative signals.

Excerpted from Wikipedia’s “PPRC1” article, available under the CC BY-SA 4.0 licence.