propionyl-CoA
Sign in to savePropionyl-CoA is a coenzyme A derivative of propionic acid. It is composed of a 24 total carbon chain (without the coenzyme, it is a 3 carbon structure) and its production and metabolic fate depend on which organism it is present in. Several different pathways can lead to its production, such as through the catabolism of specific amino acids or the oxidation of odd-chain fatty acids. It later can be broken down by propionyl-CoA carboxylase or through the methylcitrate cycle. In different organisms, however, propionyl-CoA can be sequestered into controlled regions, to alleviate its potential to
Article
16 sectionsContents
- Production
- Metabolic fate
- Reaction with propionyl-CoA carboxylase
- Mechanism
- Methylcitrate cycle
- Bacterial metabolism
- ''Mycobacterium tuberculosis'' metabolism
- Possible sequestration in ''R. sphaeroides''
- ''Escherichia coli'' metabolism
- Plant metabolism
- Fungi metabolism
- Protein Propionylation
- Human and clinical significance
- Gen5
- Propionic acidemia
- References
{{chembox | Verifiedfields = changed | verifiedrevid = 464216740 | ImageFile = Propionyl-Coenzyme A.png | ImageSize = 250px | IUPACName = 3′-O-Phosphonoadenosine 5′-{(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-[(3-oxo-3-{[2-(propanoylsulfanyl)ethyl]amino}propyl)amino]butyl dihydrogen diphosphate} | SystematicName = O1-{[(2R,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)oxolan-2-yl]methyl} O3-{(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-[(3-oxo-3-{[2-(propanoylsulfanyl)ethyl]amino}propyl)amino]butyl} dihydrogen diphosphate | OtherNames = Propionyl Coenzyme A; Propanoyl Coenzyme A |Section1= |Section2= |Section3= }}
Propionyl-CoA is a coenzyme A derivative of propionic acid. It is composed of a 24 total carbon chain (without the coenzyme, it is a 3 carbon structure) and its production and metabolic fate depend on which organism it is present in. Several different pathways can lead to its production, such as through the catabolism of specific amino acids or the oxidation of odd-chain fatty acids. It later can be broken down by propionyl-CoA carboxylase or through the methylcitrate cycle. In different organisms, however, propionyl-CoA can be sequestered into controlled regions, to alleviate its potential toxicity through accumulation. Genetic deficiencies regarding the production and breakdown of propionyl-CoA also have great clinical and human significance.