AHCY
Sign in to saveAlso known as adenosylhomocysteinase, SAHH, adoHcyase, Adenosylhomocysteinase
Adenosylhomocysteinase (, S-adenosylhomocysteine synthase, S-adenosylhomocysteine hydrolase, adenosylhomocysteine hydrolase, S-adenosylhomocysteinase, SAHase, AdoHcyase) is an enzyme that catalyzes the nicotinamide adenine dinucleotide (NAD+) dependent, reversible hydrolysis of S-adenosylhomocysteine to homocysteine and adenosine.
Key facts
- Protein family.Symbol
- AdoHcyase_NAD
- Protein family.Name
- AdoHcyase NAD-binding domain
- Protein family.image
- PDB 1ky5 EBI.jpg
- Protein family.caption
- d244e mutant s-adenosylhomocysteine hydrolase refined with noncrystallographic restraints
- Protein family.Pfam
- PF00670
- Protein family.Pfam_clan
- CL0063
- Protein family.InterPro
- IPR015878
- Protein family.PROSITE
- PDOC00603
- Protein family.SCOP
- 1b3r
via Wikipedia infobox
Gene data
AHCY- Name
- adenosylhomocysteinase
- Type
- protein-coding
- Position
- 34,280,263–34,311,802 (−)
- Aliases
- SAHH, adoHcyase
- Ensembl
- ENSG00000101444
- RefSeq RNA
- NM_000687.4, NM_001161766.2, NM_001322084.2, NM_001322085.2, NM_001322086.2
- RefSeq protein
- NP_000678.1, NP_001155238.1, NP_001309013.1, NP_001309014.1, NP_001309015.1
S-adenosylhomocysteine hydrolase belongs to the adenosylhomocysteinase family. It catalyzes the reversible hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy). Thus, it regulates the intracellular S-adenosylhomocysteine (SAH) concentration thought to be important for transmethylation reactions. Deficiency in this protein is one of the different causes of hypermethioninemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
adenosylhomocysteinase
- Symbol
- AHCY
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 20:34,280,263-34,311,802
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~2 min read
Encyclopedic overview
3 sectionsContents
- References
- External links
- Further reading
Adenosylhomocysteinase (, S-adenosylhomocysteine synthase, S-adenosylhomocysteine hydrolase, adenosylhomocysteine hydrolase, S-adenosylhomocysteinase, SAHase, AdoHcyase) is an enzyme that catalyzes the nicotinamide adenine dinucleotide (NAD+) dependent, reversible hydrolysis of S-adenosylhomocysteine to homocysteine and adenosine. S-adenosyl-L-homocysteine + H2O L-homocysteine + adenosine
AdoHcyase is a highly conserved protein with about 430 to 470 amino acids. The family contains a glycine-rich region in the central part of AdoHcyase; a region thought to be involved in NAD-binding. AdoHcyase binds one NAD+ cofactor per subunit. This protein may use the morpheein model of allosteric regulation.
Excerpted from Wikipedia’s “AHCY” article, available under the CC BY-SA 4.0 licence.