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prothioconazole

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Prothioconazole is a synthetic chemical produced primarily for its fungicidal properties. It is a member of the class of compounds triazoles, and possesses a unique toxophore in this class of fungicides. Its effective fungicidal properties can be attributed to its ability to inhibit CYP51A1. This enzyme is required to biosynthesize ergosterol, a key component in the cell membrane of fungi.

Wikidata facts

Mass
343.031
Show 3 more facts
chemical formula
C₁₄H₁₅Cl₂N₃OS
canonical SMILES
C1CC1(C(CC2=CC=CC=C2Cl)(CN3C(=S)N=CN3)O)Cl
Commons category
Prothioconazole
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~5 min read

Article

10 sections
Contents
  • Synthesis
  • Chemical properties
  • Toxicology
  • Classification
  • Toxicity
  • Metabolism in animals
  • Metabolism in plants
  • Biochemical properties
  • Interactions
  • References

Prothioconazole is a synthetic chemical produced primarily for its fungicidal properties. It is a member of the class of compounds triazoles, and possesses a unique toxophore in this class of fungicides. Its effective fungicidal properties can be attributed to its ability to inhibit CYP51A1. This enzyme is required to biosynthesize ergosterol, a key component in the cell membrane of fungi.

Prothioconazole was first introduced into the market in 2004 by Bayer CropScience and quickly gained popularity due to its broad spectrum of activity against many fungal diseases of important cereal crops. It is used as a solo product under the trade name Proline, and in various mixtures in many other commercially produced fungicides.

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