Also known as Hqk, QK, QK1, QK3, hqkI, QKI, KH domain containing, RNA binding, QKI, KH domain containing RNA binding
Quaking homolog, KH domain RNA binding (mouse), also known as QKI, is a protein which in humans is encoded by the QKI gene.
Gene data
QKI- Name
- QKI, KH domain containing RNA binding
- Type
- protein-coding
- Position
- 163,414,000–163,578,827 (+)
- Aliases
- Hqk, QK, QK1, QK3, hqkI
- Ensembl
- ENSG00000112531
- RefSeq RNA
- NM_001301085.2, NM_006775.3, NM_206853.3, NM_206854.3, NM_206855.3
- RefSeq protein
- NP_001288014.1, NP_006766.1, NP_996735.1, NP_996736.1, NP_996737.1
The protein encoded by this gene is an RNA-binding protein that regulates pre-mRNA splicing, export of mRNAs from the nucleus, protein translation, and mRNA stability. The encoded protein is involved in myelinization and oligodendrocyte differentiation and may play a role in schizophrenia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
QKI, KH domain containing RNA binding
- Symbol
- QKI
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 6:163,414,000-163,578,827
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein QKI PDB 2bl5.png
Show 7 more facts
- HomoloGene ID
- 11059
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/9444
- genomic end
- 163578592
- genomic start
- 163835032
- chromosome
- human chromosome 6
- cytogenetic location
- 6q26
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
Quaking homolog, KH domain RNA binding (mouse), also known as QKI, is a protein which in humans is encoded by the QKI gene.
QKI belongs to a family of RNA-binding proteins called STAR proteins for Signal Transduction and Activation of RNA. They have an HNRNPK homology (KH) domain embedded in a 200-amino acid region called the GSG domain. Other members of this family include SAM68 (KHDRBS1) and SF1. Two more new members are KHDRBS3 and KHDRBS2.
Excerpted from Wikipedia’s “QKI” article, available under the CC BY-SA 4.0 licence.