RAB7A
Sign in to saveAlso known as PRO2706, RAB7, RAB7A, member RAS oncogene family, CMT2B
Ras-related protein Rab-7a is a protein that in humans is encoded by the RAB7A gene.
Gene data
RAB7A- Name
- RAB7A, member RAS oncogene family
- Type
- protein-coding
- Position
- 128,693,669–128,825,942 (+)
- Aliases
- CMT2B, PRO2706, RAB7
- Ensembl
- ENSG00000075785
- RefSeq RNA
- NM_004637.6
- RefSeq protein
- NP_004628.4
RAB family members are small, RAS-related GTP-binding proteins that are important regulators of vesicular transport. Each RAB protein targets multiple proteins that act in exocytic / endocytic pathways. This gene encodes a RAB family member that regulates vesicle traffic in the late endosomes and also from late endosomes to lysosomes. This encoded protein is also involved in the cellular vacuolation of the VacA cytotoxin of Helicobacter pylori. Mutations at highly conserved amino acid residues in this gene have caused some forms of Charcot-Marie-Tooth (CMT) type 2 neuropathies. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
RAB7A, member RAS oncogene family
- Symbol
- RAB7A
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 3:128,693,669-128,825,980
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein RAB7A PDB 1t91.png
Show 5 more facts
- HomoloGene ID
- 3408
- exact match
- identifiers.org/ncbigene/7879
- genomic end
- 128825942
- genomic start
- 128693669
- cytogenetic location
- 3q21.3
Sources (6)
via Wikidata · CC0
~9 min read
Article
10 sectionsContents
- Function
- Tissue distribution
- Gene
- Regulation
- Interactions
- Clinical significance
- Melanoma
- Charcot-Marie-Tooth 2B
- References
- External links
Ras-related protein Rab-7a is a protein that in humans is encoded by the RAB7A gene.
Ras-related protein Rab-7a is involved in endocytosis, which is a process that brings substances into a cell. The process of endocytosis works by folding the cell membrane around a substance outside of the cell (for example a protein) and then forms a vesicle. The vesicle is then brought into the cell and cleaved from the cell membrane. RAB7A plays an important role in the movement of vesicles into the cell as well as with vesicle trafficking.