RASGRF2
Sign in to saveAlso known as GRF2, RAS-GRF2, Ras protein specific guanine nucleotide releasing factor 2
Ras-specific guanine nucleotide-releasing factor 2 is a protein that in humans is encoded by the RASGRF2 gene.
Gene data
RASGRF2- Name
- Ras protein specific guanine nucleotide releasing factor 2
- Type
- protein-coding
- Aliases
- GRF2, RAS-GRF2
RAS GTPases cycle between an inactive GDP-bound state and an active GTP-bound state. This gene encodes a calcium-regulated nucleotide exchange factor activating both RAS and RAS-related protein, RAC1, through the exchange of bound GDP for GTP, thereby, coordinating the signaling of distinct mitogen-activated protein kinase pathways. [provided by RefSeq, Oct 2011].
via MyGene.info
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 2169
- exact match
- identifiers.org/ncbigene/5924
- genomic end
- 81230162
- genomic start
- 80960363
- cytogenetic location
- 5q14.1
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Ras-specific guanine nucleotide-releasing factor 2 is a protein that in humans is encoded by the RASGRF2 gene.
RAS (MIM 190020) GTPases cycle between an inactive GDP-bound state and an active GTP-bound state. Guanine-nucleotide exchange factors (GEFs), such as RASGRFs, stimulate the conversion of the GDP-bound form into the active form.[supplied by OMIM]