RASGRF2

Also known as GRF2, RAS-GRF2, Ras protein specific guanine nucleotide releasing factor 2

Ras-specific guanine nucleotide-releasing factor 2 is a protein that in humans is encoded by the RASGRF2 gene.

Gene data

RASGRF2

Name: Ras protein specific guanine nucleotide releasing factor 2
Type: protein-coding
Position: 80,960,234–81,230,166 (+)
Aliases: GRF2, RAS-GRF2
Ensembl: ENSG00000113319
RefSeq RNA: NM_006909.3, XM_005248565.2, XM_017009683.2, XM_047417463.1, XM_047417464.1
RefSeq protein: NP_008840.1, XP_005248622.1, XP_016865172.1, XP_047273419.1, XP_047273420.1

RAS GTPases cycle between an inactive GDP-bound state and an active GTP-bound state. This gene encodes a calcium-regulated nucleotide exchange factor activating both RAS and RAS-related protein, RAC1, through the exchange of bound GDP for GTP, thereby, coordinating the signaling of distinct mitogen-activated protein kinase pathways. [provided by RefSeq, Oct 2011].

Gene Ontology

Biological process

small GTPase-mediated signal transduction Ras protein signal transduction response to endoplasmic reticulum stress response to endoplasmic reticulum stress regulation of small GTPase mediated signal transduction postsynaptic modulation of chemical synaptic transmission

Molecular function

guanyl-nucleotide exchange factor activity guanyl-nucleotide exchange factor activity guanyl-nucleotide exchange factor activity guanyl-nucleotide exchange factor activity

Cellular component

cytoplasm endoplasmic reticulum endoplasmic reticulum membrane cytosol plasma membrane plasma membrane plasma membrane postsynapse

Pathways

MAPK signaling pathway - Homo sapiens (human)Ras signaling pathway - Homo sapiens (human)Neurotransmitter receptors and postsynaptic signal transmission Transmission across Chemical Synapses Neuronal System Signal Transduction NRAGE signals death through JNK p75 NTR receptor-mediated signalling Signaling by Rho GTPases Cell death signalling via NRAGE, NRIF and NADE

via MyGene.info

Gene · Ensembl

Ras protein specific guanine nucleotide releasing factor 2

Symbol: RASGRF2
Biotype: Protein coding
Organism: Homo sapiens
Location: 5:80,960,234-81,230,166
Strand: Forward (+)
Assembly: GRCh38

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via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 9 more facts

HomoloGene ID: 2169
found in taxon: Homo sapiens
genetic association: cleft lip and cleft palate
exact match: identifiers.org/ncbigene/5924
genomic end: 81230162
genomic start: 80960363
chromosome: human chromosome 5
cytogenetic location: 5q14.1
expressed in: occipital lobe

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Encyclopedic overview

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Contents

References
Further reading

Ras-specific guanine nucleotide-releasing factor 2 is a protein that in humans is encoded by the RASGRF2 gene.

RAS (MIM 190020) GTPases cycle between an inactive GDP-bound state and an active GTP-bound state. Guanine-nucleotide exchange factors (GEFs), such as RASGRFs, stimulate the conversion of the GDP-bound form into the active form.[supplied by OMIM]

Excerpted from Wikipedia’s “RASGRF2” article, available under the CC BY-SA 4.0 licence.

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