Gene data
RASGRP2- Name
- RAS guanyl releasing protein 2
- Type
- protein-coding
- Position
- 64,726,905–64,745,456 (−)
- Aliases
- CALDAG-GEFI, CDC25L
- Ensembl
- ENSG00000068831
- RefSeq RNA
- NM_001098670.2, NM_001098671.2, NM_001318398.2, NM_001440690.1, NM_001440691.1
- RefSeq protein
- NP_001092140.1, NP_001092141.1, NP_001305327.1, NP_001427619.1, NP_001427620.1
The protein encoded by this gene is a brain-enriched nucleotide exchanged factor that contains an N-terminal GEF domain, 2 tandem repeats of EF-hand calcium-binding motifs, and a C-terminal diacylglycerol/phorbol ester-binding domain. This protein can activate small GTPases, including RAS and RAP1/RAS3. The nucleotide exchange activity of this protein can be stimulated by calcium and diacylglycerol. Four alternatively spliced transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2016].
Gene Ontology
Biological process
Molecular function
Pathways
MAPK signaling pathway - Homo sapiens (human)Ras signaling pathway - Homo sapiens (human)Rap1 signaling pathway - Homo sapiens (human)Chemokine signaling pathway - Homo sapiens (human)Platelet activation - Homo sapiens (human)Pathways in cancer - Homo sapiens (human)HemostasisHemostasisEffects of PIP2 hydrolysisAdaptive Immune System
via MyGene.info
Gene · Ensembl
RAS guanyl releasing protein 2
- Symbol
- RASGRP2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 11:64,726,905-64,745,456
- Strand
- Reverse (−)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 4250
- exact match
- identifiers.org/ncbigene/10235
- found in taxon
- Homo sapiens
- genomic end
- 64512928
- genomic start
- 64494383
- chromosome
- human chromosome 11
- cytogenetic location
- 11q13.1
- expressed in
- left coronary artery
Sources (6)
via Wikidata · CC0