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GeneQ18047199· pop 5· linked from 8 articles

RASSF5

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Also known as Maxp1, NORE1, NORE1A, NORE1B, RAPL, RASSF3, Ras association domain family member 5

Ras association domain-containing protein 5 is a protein that in humans is encoded by the RASSF5 or F5 gene.

Gene data

RASSF5
Name
Ras association domain family member 5
Type
protein-coding
Position
206,507,521–206,603,589 (+)
Aliases
Maxp1, NORE1, NORE1A, NORE1B, RAPL
Ensembl
ENSG00000266094
RefSeq RNA
NM_031437.1, NM_182663.4, NM_182664.4, NM_182665.4
RefSeq protein
NP_872604.1, NP_872605.1, NP_872606.1

This gene is a member of the Ras association domain family. It functions as a tumor suppressor, and is inactivated in a variety of cancers. The encoded protein localizes to centrosomes and microtubules, and associates with the GTP-activated forms of Ras, Rap1, and several other Ras-like small GTPases. The protein regulates lymphocyte adhesion and suppresses cell growth in response to activated Rap1 or Ras. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

Gene Ontology

Pathways

Ras signaling pathway - Homo sapiens (human)Rap1 signaling pathway - Homo sapiens (human)Cellular senescence - Homo sapiens (human)Leukocyte transendothelial migration - Homo sapiens (human)Pathways in cancer - Homo sapiens (human)Non-small cell lung cancer - Homo sapiens (human)Fibrin Complement Receptor 3 Signaling PathwayRas signalingNon-small cell lung cancerOverview of leukocyte-intrinsic Hippo pathway functions

via MyGene.info

Gene · Ensembl

Ras association domain family member 5

Symbol
RASSF5
Biotype
Protein coding
Organism
Homo sapiens
Location
1:206,507,521-206,603,589
Strand
Forward (+)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of
gene
Image
Protein RASSF5 PDB 2fnf.png
Show 7 more facts
HomoloGene ID
10296
found in taxon
Homo sapiens
exact match
identifiers.org/ncbigene/83593
chromosome
human chromosome 1
genomic start
206507531
genomic end
206762616
cytogenetic location
1q32.1
Sources (3)

via Wikidata · CC0

~1 min read

Encyclopedic overview

4 sections
Contents
  • Function
  • Interactions
  • References
  • Further reading

Ras association domain-containing protein 5 is a protein that in humans is encoded by the RASSF5 or F5 gene.

== Function ==

Excerpted from Wikipedia’s “RASSF5” article, available under the CC BY-SA 4.0 licence.

Available in 5 languages

via Wikidata sitelinks · CC0