RASSF1
Sign in to saveAlso known as 123F2, NORE2A, RASSF1A, RDA32, REH3P21, Ras association domain family member 1
Ras association domain-containing protein 1 is a protein that in humans is encoded by the RASSF1 gene.
Gene data
RASSF1- Name
- Ras association domain family member 1
- Type
- protein-coding
- Position
- 50,329,782–50,340,980 (−)
- Aliases
- 123F2, NORE2A, RASSF1A, RDA32, REH3P21
- Ensembl
- ENSG00000068028
- RefSeq RNA
- NM_001206957.2, NM_007182.5, NM_170712.3, NM_170713.3, NM_170714.2
- RefSeq protein
- NP_001193886.1, NP_009113.3, NP_733830.1, NP_733831.1, NP_733832.1
This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Several alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, May 2011].
Gene Ontology
Biological process
Pathways
via MyGene.info
Gene · Ensembl
Ras association domain family member 1
- Symbol
- RASSF1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 3:50,329,782-50,340,980
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~4 min read
Encyclopedic overview
4 sectionsContents
- Function
- Interactions
- Pathology
- References
Ras association domain-containing protein 1 is a protein that in humans is encoded by the RASSF1 gene.
== Function ==
Excerpted from Wikipedia’s “RASSF1” article, available under the CC BY-SA 4.0 licence.