RBFOX2

Also known as FOX2, Fox-2, HNRBP2, HRNBP2, RBM9, RTA, dJ106I20.3, fxh

RNA binding motif protein 9 (RBM9), also known as Rbfox2, is a protein which in humans is encoded by the RBM9 gene.

Gene data

RBFOX2

Name: RNA binding fox-1 homolog 2
Type: protein-coding
Position: 35,738,736–36,028,824 (−)
Aliases: FOX2, Fox-2, HNRBP2, HRNBP2, RBM9, RTA, dJ106I20.3, fxh
Ensembl: ENSG00000277564
RefSeq RNA: NM_001031695.4, NM_001082576.3, NM_001082577.3, NM_001082578.4, NM_001082579.3
RefSeq protein: NP_001026865.1, NP_001076045.1, NP_001076046.1, NP_001076047.2, NP_001076048.2

This gene is one of several human genes similar to the C. elegans gene Fox-1. This gene encodes an RNA binding protein that is thought to be a key regulator of alternative exon splicing in the nervous system and other cell types. The protein binds to a conserved UGCAUG element found downstream of many alternatively spliced exons and promotes inclusion of the alternative exon in mature transcripts. The protein also interacts with the estrogen receptor 1 transcription factor and regulates estrogen receptor 1 transcriptional activity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].