REG1A

Also known as ICRF, P19, PSP, PSPS, PSPS1, PTP, REG, regenerating family member 1 alpha

Gene data

REG1A

Name: regenerating family member 1 alpha
Type: protein-coding
Position: 79,120,362–79,123,409 (+)
Aliases: ICRF, P19, PSP, PSPS, PSPS1, PTP, REG
Ensembl: ENSG00000115386
RefSeq RNA: NM_002909.5
RefSeq protein: NP_002900.2

This gene is a type I subclass member of the Reg gene family. The Reg gene family is a multigene family grouped into four subclasses, types I, II, III and IV, based on the primary structures of the encoded proteins. This gene encodes a protein that is secreted by the exocrine pancreas. It is associated with islet cell regeneration and diabetogenesis and may be involved in pancreatic lithogenesis. Reg family members REG1B, REGL, PAP and this gene are tandemly clustered on chromosome 2p12 and may have arisen from the same ancestral gene by gene duplication. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

signal transduction positive regulation of cell population proliferation positive regulation of cell population proliferation response to peptide hormone antimicrobial humoral immune response mediated by antimicrobial peptide

Molecular function

hormone activity protein binding growth factor activity growth factor activity molecular function inhibitor activity

Cellular component

extracellular region extracellular region extracellular exosome

Pathways

Developmental Biology Developmental Cell Lineages Developmental Cell Lineages of the Exocrine Pancreas Developmental Lineage of Pancreatic Acinar Cells Insulin Signaling Type II interferon signaling (IFNG)

via MyGene.info

Wikidata facts

Image: Protein REG1A PDB 1lit.png

Show 5 more facts

HomoloGene ID: 68282
exact match: identifiers.org/ncbigene/5967
genomic end: 79123409
genomic start: 79347488
cytogenetic location: 2p12

Sources (4)

via Wikidata · CC0

~2 min read

Article

5 sections

Contents

Function
Pancreas development and regeneration
Sepsis
References
Further reading

Pancreatic Stone Protein (PSP), also known as Lithostathine-1-alpha islet cells regeneration factor (ICRF) or islet of Langerhans regenerating protein (REG) is a protein that in humans is encoded by the REG1A gene as a single polypeptide of 144 amino acids further cleaved by trypsin to produce a 133 amino acid protein that is O-linked glycosylated on threonine 27. This protein is a type I subclass member of the Regenerating protein family. The Reg protein family is a multi protein family grouped into four subclasses, types I, II, III and IV based on the primary structures of the proteins. Reg family members REG1B, REGL, PAP and this gene are tandemly clustered on chromosome 2p12 and may have arisen from the same ancestral gene by gene duplication. The PSP is mostly produced in Human by the acinar cells of the pancreas and is secreted in the duodenum by the same pathway that pancreatic exocrine enzymes. It has C-terminal C-type lectin domain whose binding partner is currently unknown.

== Function == === Pancreas development and regeneration === The PSP has been shown to be associated with islet cell regeneration and diabetogenesis and may be involved in pancreatic lithogenesis (creation of pancreatic stones; pancreatic calculi).