regulon
Sign in to saveAlso known as regulons
In molecular genetics, a regulon is a group of genes that are regulated as a unit, generally controlled by the same regulatory gene that expresses a protein acting as a repressor or activator. This terminology is generally, although not exclusively, used in reference to prokaryotes, whose genomes are often organized into operons; the genes contained within a regulon are usually organized into more than one operon at disparate locations on the chromosome. Applied to eukaryotes, the term refers to any group of non-contiguous genes controlled by the same regulatory gene.
Research
8,030 papers- Integrated analysis of single-cell and bulk RNA sequencing data reveals a myeloid cell-related regulon predicting neoadjuvant immunotherapy response across cancers.Journal of translational medicine · 2024
- Regulon: An overview of plant abiotic stress transcriptional regulatory system and role in transgenic plants.Brazilian journal of biology = Revista brasleira de biologia · 2021
- P-Body Purification Reveals the Condensation of Repressed mRNA Regulons.Molecular cell · 2017
- A post-transcriptional respiratome regulon in trypanosomes.Nucleic acids research · 2019
- Condition-dependent transcriptome reveals high-level regulatory architecture in Bacillus subtilis.Science (New York, N.Y.) · 2012
via PubMed
~2 min read
Encyclopedic overview
4 sectionsContents
- Examples
- Evolution
- References
- External links
In molecular genetics, a regulon is a group of genes that are regulated as a unit, generally controlled by the same regulatory gene that expresses a protein acting as a repressor or activator. This terminology is generally, although not exclusively, used in reference to prokaryotes, whose genomes are often organized into operons; the genes contained within a regulon are usually organized into more than one operon at disparate locations on the chromosome. Applied to eukaryotes, the term refers to any group of non-contiguous genes controlled by the same regulatory gene.
A modulon is a set of regulons or operons that are collectively regulated in response to changes in overall conditions or stresses, but may be under the control of different or overlapping regulatory molecules. The term stimulon is sometimes used to refer to the set of genes whose expression responds to specific environmental stimuli.
Excerpted from Wikipedia’s “regulon” article, available under the CC BY-SA 4.0 licence.