cyclin dependent kinase 1
Sign in to saveAlso known as cell cycle controller CDC2, cell division control protein 2 homolog, p34 protein kinase, cyclin-dependent kinase 1, cell division protein kinase 1, CDK1, cell division cycle 2, G1 to S and G2 to M
mammalian protein found in Homo sapiens
Protein · UniProt
Cyclin-dependent kinase 1
- Gene
- CDK1
- Organism
- Homo sapiens (Human)
- Length
- 297 aa
- Molecular mass
- 34,095 Da
- Evidence
- 1: Evidence at protein level
Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition via association with multiple interphase cyclins (PubMed:16407259, PubMed:16933150, PubMed:17459720, PubMed:18356527, PubMed:19509060, PubMed:19917720, PubMed:20171170, PubMed:20935635, PubMed:20937773, PubMed:21063390, PubMed:2188730, PubMed:23355470, PubMed:2344612, PubMed:23601106, PubMed:23602554, PubMed:25556658, PubMed:26829474, PubMed:27814491, PubMed:30139873, PubMed:30704899, PubMed:40440427). Phosphorylates PARVA/actopaxin, APC, AMPH, A…
Swiss-Prot (reviewed) · via UniProt
Research
9,778 papers- Cyclin-dependent kinase 1 (CDK1) in cancers: from upstream regulation to downstream substrates and therapeutic inhibitors.European journal of medicinal chemistry · 2025
- Inhibition of CDK1 Overcomes Oxaliplatin Resistance by Regulating ACSL4-mediated Ferroptosis in Colorectal Cancer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
- Multiple Functional Protein-Protein Interaction Interfaces Allosterically Regulate ATP-Binding in Cyclin-Dependent Kinase-1.Proteins · 2024
- Triggering mitosis.FEBS letters · 2019
- Overexpression of cyclin-dependent kinase 1 in esophageal squamous cell carcinoma and its clinical significance.FEBS open bio · 2021
via PubMed
Clinical Trials
29 registered- PHASE1COMPLETEDA Study of PRT2527 as Monotherapy and in Combination With Zanubrutinib or Venetoclax in Participants With R/R Hematologic MalignanciesPrelude Therapeutics · NCT05665530
- COMPLETEDTreatment of Canadian Men and Pre/Peri/Post-menopausal Women With ER+ Advanced Breast Cancer in the Real-World Setting With Hormone Therapy ± Targeted TherapyNovartis Pharmaceuticals · NCT02753686
- PHASE1COMPLETEDA Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of PF-06842874 in Healthy ParticipantsPfizer · NCT04124653
- PHASE1COMPLETEDPhase I Trial of BAY1251152 for Advanced Blood CancersBayer · NCT02745743
- PHASE1COMPLETEDA Study to Understand What the Body Does to the Study Medicine Called PF-07220060 When Taken by Healthy AdultsPfizer · NCT06267963
- PHASE1WITHDRAWNStudy of PF-07224826, as a Single Agent or in Combination With Endocrine Therapy in Participants With Breast Cancer and Other Advanced Solid Tumors.Pfizer · NCT05905341
Wikidata facts
- Instance of
- protein
- Image
- CDK1 .png
Show 2 more facts
- cell component
- mitotic spindle
- found in taxon
- Homo sapiens
via Wikidata · CC0