REV1
Sign in to saveAlso known as REV1L, AIBP80, REV1, DNA directed polymerase, REV1 DNA directed polymerase
DNA repair protein REV1 is a protein that in humans is encoded by the REV1 gene.
Gene data
REV1- Name
- REV1 DNA directed polymerase
- Type
- protein-coding
- Position
- 99,400,475–99,490,466 (−)
- Aliases
- AIBP80, REV1L
- Ensembl
- ENSG00000135945
- RefSeq RNA
- NM_001037872.3, NM_001321454.2, NM_001321455.2, NM_001321458.2, NM_001321459.2
- RefSeq protein
- NP_001032961.1, NP_001308383.1, NP_001308384.1, NP_001308387.1, NP_001308388.1
This gene encodes a protein with similarity to the S. cerevisiae mutagenesis protein Rev1. The Rev1 proteins contain a BRCT domain, which is important in protein-protein interactions. A suggested role for the human Rev1-like protein is as a scaffold that recruits DNA polymerases involved in translesion synthesis (TLS) of damaged DNA. [provided by RefSeq, Mar 2016].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
REV1 DNA directed polymerase
- Symbol
- REV1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 2:99,400,475-99,490,466
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein REV1 PDB 2EBW.png
Show 7 more facts
- HomoloGene ID
- 32309
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/51455
- genomic end
- 100106497
- genomic start
- 100016938
- chromosome
- human chromosome 2
- cytogenetic location
- 2q11.2
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
4 sectionsContents
- Interactions
- See also
- References
- Further reading
DNA repair protein REV1 is a protein that in humans is encoded by the REV1 gene.
This gene encodes a protein with similarity to the S. cerevisiae mutagenesis protein Rev1. The Rev1 proteins contain a BRCT domain, which is important in protein-protein interactions. A suggested role for the human Rev1-like protein is as a scaffold that recruits DNA polymerases involved in translesion synthesis (TLS) of damaged DNA. Two alternatively spliced transcript variants that encode different proteins have been found.
Excerpted from Wikipedia’s “REV1” article, available under the CC BY-SA 4.0 licence.