REV3L
Sign in to saveAlso known as POLZ, REV3, REV3 like, DNA directed polymerase zeta catalytic subunit
Protein reversionless 3-like (REV3L) also known as DNA polymerase zeta catalytic subunit (POLZ) is an enzyme that in humans is encoded by the REV3L gene.
Gene data
REV3L- Name
- REV3 like, DNA directed polymerase zeta catalytic subunit
- Type
- protein-coding
- Aliases
- POLZ, REV3
The protein encoded by this gene represents the catalytic subunit of DNA polymerase zeta, which functions in translesion DNA synthesis. The encoded protein can be found in mitochondria, where it protects DNA from damage. Defects in this gene are a cause of Mobius syndrome. [provided by RefSeq, Jan 2017].
via MyGene.info
Gene · Ensembl
REV3 like, DNA directed polymerase zeta catalytic subunit
- Symbol
- REV3L
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 6:111,299,028-111,483,729
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein MAD2L2 PDB 3ABD.png
Show 5 more facts
- HomoloGene ID
- 48147
- exact match
- identifiers.org/ncbigene/5980
- genomic end
- 111804918
- genomic start
- 111620234
- cytogenetic location
- 6q21
Sources (3)
via Wikidata · CC0
~1 min read
Article
4 sectionsContents
- Interactions
- See also
- References
- Further reading
Protein reversionless 3-like (REV3L) also known as DNA polymerase zeta catalytic subunit (POLZ) is an enzyme that in humans is encoded by the REV3L gene.
The Rev3 subunit interacts with Rev7 to form Pol ζ, a B family polymerase. Pol ζ lacks 3' to 5' exonuclease activity and is a moderate fidelity polymerase. It cannot add nucleotides across from DNA lesions, yet it can extend from primers with terminal mismatches. This makes Pol ζ very important in translesion synthesis (TLS), because it can act in concert with other TLS polymerases that can add across the lesion to complete the bypass of the lesion. Most polymerases have difficulty extending mismatches because they cannot bind properly to the mismatched DNA. So rather than the cell dying, it can survive albeit with a mutation that may or may not be deleterious, so it is believed that Pol ζ is a driving force of evolution.