Structure via PubChem · Public domain (PubChem)
rivaroxaban
Sign in to saveRivaroxaban, sold under the brand name Xarelto among others, is an anticoagulant medication (blood thinner) used to treat and reduce the risk of blood clots. Specifically it is used to treat deep vein thrombosis and pulmonary emboli and prevent blood clots in atrial fibrillation and following hip or knee surgery. It is taken by mouth.
Key facts
- Drug.pregnancy_AU
- C
- Drug.Verifiedfields
- changed
- Drug.verifiedrevid
- 459434616
- Drug.image
- Rivaroxaban2DCSD.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 250
- Drug.image2
- Rivaroxaban xtal 2005.png
- Drug.image_class2
- bg-transparent
- Drug.width2
- 250
- Drug.tradename
- Xarelto, others
- Drug.MedlinePlus
- a611049
- Drug.DailyMedID
- Rivaroxaban
- Drug.routes_of_administration
- By mouth
- Drug.ATC_prefix
- B01
- Drug.ATC_suffix
- AF01
- Drug.legal_AU
- S4
- Drug.legal_CA
- Rx-only
- Drug.legal_UK
- POM
via Wikipedia infobox
Chemical data
- Formula
- C19H18ClN3O5S
- Molecular weight
- 435.9 g/mol
- IUPAC name
- 5-chloro-N-[[(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl]methyl]thiophene-2-carboxamide
- SMILES
- C1COCC(=O)N1C2=CC=C(C=C2)N3C[C@@H](OC3=O)CNC(=O)C4=CC=C(S4)Cl
- InChIKey
- KGFYHTZWPPHNLQ-AWEZNQCLSA-N
- XLogP
- 2.5
- Polar surface area
- 116 Ų
- H-bond donors
- 1
- H-bond acceptors
- 6
- Formal charge
- 0
via PubChem
Research
10,063 papers- Clinical pharmacokinetic and pharmacodynamic profile of rivaroxaban.Clinical pharmacokinetics · 2014
- Rivaroxaban and the EINSTEIN clinical trial programme.Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis · 2019
- Rivaroxaban for the treatment of venous thromboembolism in pediatric patients.Expert review of cardiovascular therapy · 2020
- Rivaroxaban for treatment of livedoid vasculopathy: A systematic review.Dermatologic therapy · 2021
- Rivaroxaban: A Review for Secondary CV Prevention in CAD and PAD.Drugs · 2020
via PubMed
~12 min read
Encyclopedic overview
13 sectionsContents
- Medical uses
- Contraindications
- Adverse effects
- Reversal agent
- Mechanism of action
- Chemistry
- History
- Society and culture
- Economics
- Legal status
- Legal action
- Research
- References
{{Infobox drug | Verifiedfields = changed | verifiedrevid = 459434616 | image = Rivaroxaban2DCSD.svg | image_class = skin-invert-image | width = 250 | alt = | image2 = Rivaroxaban xtal 2005.png | image_class2 = bg-transparent | width2 = 250 | alt2 =
| pronounce = | tradename = Xarelto, others | Drugs.com = | MedlinePlus = a611049 | DailyMedID = Rivaroxaban | pregnancy_AU = C | pregnancy_AU_comment = | pregnancy_category = | routes_of_administration = By mouth | class = | ATC_prefix = B01 | ATC_suffix = AF01 | ATC_supplemental =
Excerpted from Wikipedia’s “rivaroxaban” article, available under the CC BY-SA 4.0 licence.