English
Structure via PubChem · Public domain (PubChem)
roquinimex
Sign in to saveAlso known as Linomide
Linomide (Roquinimex) is a quinoline derivative immunostimulant which increases NK cell activity and macrophage cytotoxicity. It also inhibits angiogenesis and reduces the secretion of TNF alpha.
Chemical data
- Formula
- C18H16N2O3
- Molecular weight
- 308.3 g/mol
- IUPAC name
- 4-hydroxy-N,1-dimethyl-2-oxo-N-phenylquinoline-3-carboxamide
- SMILES
- CN1C2=CC=CC=C2C(=C(C1=O)C(=O)N(C)C3=CC=CC=C3)O
- InChIKey
- SGOOQMRIPALTEL-UHFFFAOYSA-N
- XLogP
- 2.7
- Polar surface area
- 60.9 Ų
- H-bond donors
- 1
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 308.1160923719999
Show 3 more facts
- canonical SMILES
- CN1C2=CC=CC=C2C(=C(C1=O)C(=O)N(C)C3=CC=CC=C3)O
- chemical formula
- C₁₈H₁₆N₂O₃
- subject has role
- angiogenesis inhibitor
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- Synthesis
- References
Linomide (Roquinimex) is a quinoline derivative immunostimulant which increases NK cell activity and macrophage cytotoxicity. It also inhibits angiogenesis and reduces the secretion of TNF alpha.
Linomide has been investigated as a treatment for some cancers (including as adjuvant therapy after bone marrow transplantation in acute leukemia) and autoimmune diseases, such as multiple sclerosis and recent-onset type I diabetes. Several trials have been terminated due to serious cardiovascular toxicity.
Excerpted from Wikipedia’s “roquinimex” article, available under the CC BY-SA 4.0 licence.