RSPO1

Name

R-spondin 1

Type

protein-coding

Aliases

CRISTIN3, RSPO

This gene encodes a secreted activator protein with two cysteine-rich, furin-like domains and one thrombospondin type 1 domain. The encoded protein is a ligand for leucine-rich repeat-containing G-protein coupled receptors (LGR proteins) and positively regulates the Wnt signaling pathway. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014].

via MyGene.info

Gene · Ensembl

R-spondin 1

Symbol

RSPO1

Biotype

Protein coding

Organism

Homo sapiens

Location

1:37,610,802-37,635,604

Strand

Reverse (−)

Assembly

GRCh38