thrombospondins
Sign in to saveAlso known as thrombospondin, Thrombospondin
Thrombospondins (TSPs) are a family of secreted glycoproteins with antiangiogenic functions. Due to their dynamic role within the extracellular matrix they are considered matricellular proteins. The first member of the family, thrombospondin 1 (THBS1), was discovered in 1971 by Nancy L. Baenziger.
Research
10,662 papers- Thrombospondins in the tumor microenvironment.Seminars in cell & developmental biology · 2024
- Thrombospondins: Conserved mediators and modulators of metazoan extracellular matrix.International journal of experimental pathology · 2024
- Structures of thrombospondins.Cellular and molecular life sciences : CMLS · 2008
- Thrombospondins and tumor angiogenesis.Trends in molecular medicine · 2001
- The Role of Thrombospondins in Osteoarthritis: from Molecular Mechanisms to Therapeutic Potential.International journal of biological sciences · 2025
via PubMed
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Encyclopedic overview
5 sectionsContents
- Types
- Thrombospondin 1
- Human proteins containing this domain
- References
- External links
Thrombospondins (TSPs) are a family of secreted glycoproteins with antiangiogenic functions. Due to their dynamic role within the extracellular matrix they are considered matricellular proteins. The first member of the family, thrombospondin 1 (THBS1), was discovered in 1971 by Nancy L. Baenziger.
== Types == The thrombospondins are a family of multifunctional proteins. The family consists of thrombospondins 1–5 and can be divided into two subgroups: A, which contains TSP-1 and TSP-2, and B, which contains TSP-3, TSP-4 and TSP-5 (also designated cartilage oligomeric protein or COMP). TSP-1 and TSP-2 are homotrimers, consisting of three identical subunits, whereas TSP-3, TSP-4 and TSP-5 are homopentamers.
Excerpted from Wikipedia’s “thrombospondins” article, available under the CC BY-SA 4.0 licence.