SCGN

Secretagogin is a protein that in humans is encoded by the SCGN gene.

== Expression == Secretagogin is expressed in a variety of organs and tissues. It is expressed in pancreatic β cells, where it participates in insulin release. In the brain, it is expressed in interneurons and pyramidal cells of the hippocampus. In the brainstem, it is expressed neurons of the superior colliculus, cuneiform nucleus, locus coeruleus, and solitary tract nucleus. In the spinal cord, secretagogin is expressed in the dorsal horn and dorsal root ganglia (up to 7% of DRGs) where it is co-expressed with calcitonin gene-related peptide (CGRP). Secretagogin is also expressed in the sciatic nerve. In gut tissue, secretagogin is expressed in 10% of enteric neurons of the small intestine, while it is expressed in 5% of enteric neurons of the proximal colon, and 25% in the distal colon. Single-cell RNA sequencing of human and mouse intestinal tissue suggests that secretagogin is also expressed in about 15% of enteroendocrine cells.