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senicapoc

Structure via PubChem · Public domain (PubChem)

EntityQ7450628· pop 6· linked from 2 articles

Also known as ICA-17043

Senicapoc (ICA-17043) is a Gardos channel blocker.

Chemical data

Formula
C20H15F2NO
Molecular weight
323.3 g/mol
IUPAC name
2,2-bis(4-fluorophenyl)-2-phenylacetamide

via PubChem

Drug data · ChEMBL

Max clinical phase
Phase 3
Molecule type
Small molecule
Indications
severe acute respiratory syndrome, COVID-19, asthma, sickle cell anemia

via ChEMBL · EBI

Wikidata facts

Mass
323.112
Show 2 more facts
chemical formula
C₂₀H₁₅F₂NO
canonical SMILES
C1=CC=C(C=C1)C(C2=CC=C(C=C2)F)(C3=CC=C(C=C3)F)C(=O)N
Sources (2)

via Wikidata · CC0

~1 min read

Encyclopedic overview

1 sections
Contents
  • References

Senicapoc (ICA-17043) is a Gardos channel blocker.

It has been proposed for use in sickle cell anemia. Gardos channel blockers may work in the treatment of sickle cell anemia by blocking the efflux of potassium and water from red blood cells, thereby preventing the dehydration of red blood cells and stopping the polymerization of HbS.

Excerpted from Wikipedia’s “senicapoc” article, available under the CC BY-SA 4.0 licence.

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