SF3B1
Sign in to saveAlso known as Hsh155, MDS, PRP10, PRPF10, SAP155, SF3b155, splicing factor 3b subunit 1
Splicing factor 3B subunit 1 is a protein that in humans is encoded by the SF3B1 gene.
Gene data
SF3B1- Name
- splicing factor 3b subunit 1
- Type
- protein-coding
- Position
- 197,388,515–197,435,079 (−)
- Aliases
- Hsh155, MDS, PRP10, PRPF10, SAP155, SF3b155
- Ensembl
- ENSG00000115524
- RefSeq RNA
- NM_001005526.2, NM_001308824.1, NM_012433.4, XM_047443838.1, XM_047443839.1
- RefSeq protein
- NP_001005526.1, NP_001295753.1, NP_036565.2, XP_047299794.1, XP_047299795.1
This gene encodes subunit 1 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. The carboxy-terminal two-thirds of subunit 1 have 22 non-identical, tandem HEAT repeats that form rod-like, helical structures. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
splicing factor 3b subunit 1
- Symbol
- SF3B1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 2:197,388,515-197,435,079
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~2 min read
Encyclopedic overview
6 sectionsContents
- Function
- Interactions
- Clinical relevance
- Inhibitors
- References
- Further reading
Splicing factor 3B subunit 1 is a protein that in humans is encoded by the SF3B1 gene.
== Function ==
Excerpted from Wikipedia’s “SF3B1” article, available under the CC BY-SA 4.0 licence.