SF3B3
Sign in to saveAlso known as RSE1, SAP130, SF3b130, STAF130, splicing factor 3b subunit 3
Splicing factor 3B subunit 3 is a protein that in humans is encoded by the SF3B3 gene.
Gene data
SF3B3- Name
- splicing factor 3b subunit 3
- Type
- protein-coding
- Aliases
- RSE1, SAP130, SF3b130, STAF130
This gene encodes subunit 3 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 3 has also been identified as a component of the STAGA (SPT3-TAF(II)31-GCN5L acetylase) transcription coactivator-HAT (histone acetyltransferase) complex, and the TFTC (TATA-binding-protein-free TAF(II)-containing complex). These complexes may function in chromatin modification, transcription, splicing, and DNA repair. [provided by RefSeq, Jul 2008].
via MyGene.info
Gene · Ensembl
splicing factor 3b subunit 3
- Symbol
- SF3B3
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 16:70,523,782-70,577,670
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 6579
- exact match
- identifiers.org/ncbigene/23450
- genomic end
- 70608820
- genomic start
- 70523791
- cytogenetic location
- 16q22.1
Sources (4)
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Splicing factor 3B subunit 3 is a protein that in humans is encoded by the SF3B3 gene.
This gene encodes subunit 3 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 3 has also been identified as a component of the STAGA (SPT3-TAF(II)31-GCN5L acetylase) transcription coactivator-HAT (histone acetyltransferase) complex, and the TFTC (TATA-binding-protein-free TAF(II)-containing complex). These complexes may function in chromatin modification, transcription, splicing, and DNA repair.