shelterin complex
Sign in to saveAlso known as Pot1 complex, Pot1-Tpz1 complex, telosome, GO:0070187, shelterin complexes
Shelterin (also called telosome) is a protein complex known to protect telomeres in many eukaryotes from DNA repair mechanisms, as well as to regulate telomerase activity. In mammals and other vertebrates, telomeric DNA consists of repeating double-stranded 5'-TTAGGG-3' (G-strand) sequences (2-15 kilobases in humans) along with the 3'-AATCCC-5' (C-strand) complement, ending with a 50-400 nucleotide 3' (G-strand) overhang. Much of the final double-stranded portion of the telomere forms a T-loop (Telomere-loop) that is invaded by the 3' (G-strand) overhang to form a small D-l
Research
2,224 papers- Shelterin: the protein complex that shapes and safeguards human telomeres.Genes & development · 2005
- The structural biology of the shelterin complex.Biological chemistry · 2019
- The shelterin complex and hematopoiesis.The Journal of clinical investigation · 2016
- Shelterin is a dimeric complex with extensive structural heterogeneity.Proceedings of the National Academy of Sciences of the United States of America · 2022
- Structural biology of telomeres and telomerase.Cellular and molecular life sciences : CMLS · 2020
via PubMed
~7 min read
Encyclopedic overview
6 sectionsContents
- Subunits
- Repression of [[DNA repair]] mechanisms
- Species differences
- Non-telomeric functions of shelterin proteins
- See also
- References
Shelterin (also called telosome) is a protein complex known to protect telomeres in many eukaryotes from DNA repair mechanisms, as well as to regulate telomerase activity. In mammals and other vertebrates, telomeric DNA consists of repeating double-stranded 5'-TTAGGG-3' (G-strand) sequences (2-15 kilobases in humans) along with the 3'-AATCCC-5' (C-strand) complement, ending with a 50-400 nucleotide 3' (G-strand) overhang. Much of the final double-stranded portion of the telomere forms a T-loop (Telomere-loop) that is invaded by the 3' (G-strand) overhang to form a small D-loop (Displacement-loop).
The absence of shelterin causes telomere uncapping and thereby activates damage-signaling pathways that may lead to non-homologous end joining (NHEJ), homology directed repair (HDR), end-to-end fusions, genomic instability, senescence, or apoptosis.
Excerpted from Wikipedia’s “shelterin complex” article, available under the CC BY-SA 4.0 licence.