SIL1

Also known as BAP, MSS, ULG5, SIL1 nucleotide exchange factor

Nucleotide exchange factor SIL1 is a protein encoded in humans by the SIL1 gene.

Gene data

SIL1

Name: SIL1 nucleotide exchange factor
Type: protein-coding
Position: 138,886,914–139,293,557 (−)
Aliases: BAP, MSS, ULG5
Ensembl: ENSG00000120725
RefSeq RNA: NM_001037633.2, NM_022464.5, XM_011543570.3, XM_047417496.1, XM_047417498.1
RefSeq protein: NP_001032722.1, NP_071909.1, XP_011541872.1, XP_047273452.1, XP_047273454.1

This gene encodes a resident endoplasmic reticulum (ER), N-linked glycoprotein with an N-terminal ER targeting sequence, 2 putative N-glycosylation sites, and a C-terminal ER retention signal. This protein functions as a nucleotide exchange factor for another unfolded protein response protein. Mutations in this gene have been associated with Marinesco-Sjogren syndrome. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

protein folding cotranslational protein targeting to membrane intracellular protein transport

Molecular function

adenyl-nucleotide exchange factor activity adenyl-nucleotide exchange factor activity protein binding identical protein binding

Cellular component

extracellular region endoplasmic reticulum endoplasmic reticulum endoplasmic reticulum endoplasmic reticulum endoplasmic reticulum lumen

Pathways

Protein processing in endoplasmic reticulum - Homo sapiens (human)

via MyGene.info

Gene · Ensembl

SIL1 nucleotide exchange factor

Symbol: SIL1
Biotype: Protein coding
Organism: Homo sapiens
Location: 5:138,886,914-139,293,557
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

~5 min read

Encyclopedic overview

7 sections

Contents

Discovery and expression
Structure and mechanism of nucleotide exchange
Tissue expression
Interactions
References
Further reading
External links

Nucleotide exchange factor SIL1 is a protein encoded in humans by the SIL1 gene.

This gene encodes a resident endoplasmic reticulum (ER) N-linked glycoprotein with an N-terminal ER targeting sequence, two putative N-glycosylation sites, and a C-terminal ER retention signal. This protein functions as a nucleotide exchange factor for another unfolded protein response protein. Mutations in this gene have been associated with Marinesco-Sjogren syndrome. Alternative transcriptional splice variants have been characterized.

Excerpted from Wikipedia’s “SIL1” article, available under the CC BY-SA 4.0 licence.