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GeneQ18031512· pop 6· linked from 5 articles

SKIL

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Also known as SNO, SnoA, SnoI, SnoN, SKI-like proto-oncogene, SKI like proto-oncogene

Ski-like protein is a protein that in humans is encoded by the SKIL gene.

Gene data

SKIL

Name: SKI like proto-oncogene
Type: protein-coding
Position: 170,357,287–170,396,848 (+)
Aliases: SNO, SnoA, SnoI, SnoN
Ensembl: ENSG00000136603
RefSeq RNA: NM_001145097.2, NM_001145098.3, NM_001248008.1, NM_005414.5, XM_005247721.2
RefSeq protein: NP_001138569.1, NP_001138570.1, NP_001234937.1, NP_005405.2, XP_005247778.1

The protein encoded by this gene is a component of the SMAD pathway, which regulates cell growth and differentiation through transforming growth factor-beta (TGFB). In the absence of ligand, the encoded protein binds to the promoter region of TGFB-responsive genes and recruits a nuclear repressor complex. TGFB signaling causes SMAD3 to enter the nucleus and degrade this protein, allowing these genes to be activated. Four transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].

Gene Ontology

Biological process

negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II spermatogenesis skeletal muscle tissue development negative regulation of transforming growth factor beta receptor signaling pathway negative regulation of transforming growth factor beta receptor signaling pathway negative regulation of transforming growth factor beta receptor signaling pathway negative regulation of BMP signaling pathway

Molecular function

RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific chromatin binding protein binding protein domain specific binding

Cellular component

acrosomal vesicle nucleus nucleus nucleus nucleoplasm nucleoplasm transcription regulator complex cytoplasm

Pathways

Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)Signal Transduction Signal Transduction Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex Generic Transcription Pathway Generic Transcription Pathway Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Downregulation of SMAD2/3:SMAD4 transcriptional activity

via MyGene.info

Gene · Ensembl

SKI like proto-oncogene

Symbol: SKIL
Biotype: Protein coding
Organism: Homo sapiens
Location: 3:170,357,287-170,396,848
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

~1 min read

Encyclopedic overview

4 sections

Contents

Interactions
Protein Family
References
Further reading

Ski-like protein is a protein that in humans is encoded by the SKIL gene.

==Interactions== SKIL interacts with SKI protein, Mothers against decapentaplegic homolog 3 and Mothers against decapentaplegic homolog 2.

Excerpted from Wikipedia’s “SKIL” article, available under the CC BY-SA 4.0 licence.

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