Also known as SKI proto-oncogene, SGS, SKV
protein-coding gene in the species Homo sapiens
Gene data
SKI- Name
- SKI proto-oncogene
- Type
- protein-coding
- Position
- 2,227,388–2,310,213 (+)
- Aliases
- SGS, SKV
- Ensembl
- ENSG00000157933
- RefSeq RNA
- NM_003036.4, XM_005244775.4, XM_005244776.5, XM_017002128.2, XM_047428466.1
- RefSeq protein
- NP_003027.1, XP_005244832.1, XP_005244833.1, XP_016857617.1, XP_047284422.1
This gene encodes the nuclear protooncogene protein homolog of avian sarcoma viral (v-ski) oncogene. It functions as a repressor of TGF-beta signaling, and may play a role in neural tube development and muscle differentiation. [provided by RefSeq, Oct 2009].
Gene Ontology
Biological process
negative regulation of transcription by RNA polymerase IInegative regulation of transcription by RNA polymerase IInegative regulation of transcription by RNA polymerase IIneural tube closurelens morphogenesis in camera-type eyetransforming growth factor beta receptor signaling pathwaynegative regulation of cell population proliferationanterior/posterior axis specification
Molecular function
RNA polymerase II cis-regulatory region sequence-specific DNA bindingDNA-binding transcription factor activity, RNA polymerase II-specificDNA-binding transcription repressor activity, RNA polymerase II-specificDNA-binding transcription repressor activity, RNA polymerase II-specificprotein bindingzinc ion bindingprotein kinase bindingprotein domain specific binding
Pathways
Signal TransductionSignal TransductionSignaling by TGF-beta Receptor ComplexSignaling by TGF-beta Receptor ComplexSignaling by BMPGeneric Transcription PathwayGeneric Transcription PathwayTranscriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerTranscriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerDownregulation of SMAD2/3:SMAD4 transcriptional activity
via MyGene.info
Gene · Ensembl
SKI proto-oncogene
- Symbol
- SKI
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:2,227,388-2,310,213
- Strand
- Forward (+)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI