SLN

Also known as sarcolipin

Sarcolipin is a micropeptide protein that in humans is encoded by the SLN gene.

Gene data

SLN

Name: sarcolipin
Type: protein-coding
Position: 107,706,978–107,719,703 (−)
Ensembl: ENSG00000170290
RefSeq RNA: NM_003063.3
RefSeq protein: NP_003054.1

Sarcoplasmic reticulum Ca(2+)-ATPases are transmembrane proteins that catalyze the ATP-dependent transport of Ca(2+) from the cytosol into the lumen of the sarcoplasmic reticulum in muscle cells. This gene encodes a small proteolipid that regulates several sarcoplasmic reticulum Ca(2+)-ATPases. The transmembrane protein interacts with Ca(2+)-ATPases and reduces the accumulation of Ca(2+) in the sarcoplasmic reticulum without affecting the rate of ATP hydrolysis. [provided by RefSeq, Jul 2008].

Pathways

Transport of small molecules Muscle contraction Cardiac conduction Ion homeostasis Ion transport by P-type ATPases Ion channel transport 16p11.2 distal deletion syndrome

via MyGene.info

Gene · Ensembl

sarcolipin

Symbol: SLN
Biotype: Protein coding
Organism: Homo sapiens
Location: 11:107,706,978-107,719,703
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: Protein SLN PDB 1jdm.png

Show 6 more facts

found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/6588
genomic end: 107590419
genomic start: 107578104
chromosome: human chromosome 11
cytogenetic location: 11q22.3

Sources (3)

via Wikidata · CC0

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Encyclopedic overview

4 sections

Contents

Function
Interactions
References
Further reading

Sarcolipin is a micropeptide protein that in humans is encoded by the SLN gene.

== Function == Sarcoplasmic reticulum Ca2+-ATPases are transmembrane proteins that catalyze the ATP-dependent transport of Ca2+ from the cytosol into the lumen of the sarcoplasmic reticulum in muscle cells. The SLN gene encodes a small transmembrane proteolipid that regulates several sarcoplasmic reticulum Ca2+-ATPases by reducing the accumulation of Ca2+ in the sarcoplasmic reticulum without affecting the rate of ATP hydrolysis.

Excerpted from Wikipedia’s “SLN” article, available under the CC BY-SA 4.0 licence.