Phospholamban
Sign in to saveAlso known as cardiac phospholamban, PLN
Phospholamban, also known as PLN or PLB, is a micropeptide protein that in humans is encoded by the PLN gene. Phospholamban is a 52-amino acid integral membrane protein that regulates the calcium (Ca2+) pump in cardiac muscle cells.
In the Vinony graph
Vinony's link graph records 68 inbound references to Phospholamban, and connects out to PubMed, chelation and Ensembl genome database project.
It sits within the topics Genes on human chromosome 6, Membrane channels and Protein domains.
Vinony links it to 11 Wikipedia language editions.
Key facts
- Protein family.caption
- Phospholamban pentamer
- Protein family.Symbol
- Phospholamban
- Protein family.image
- 1zll_opm.png
- Protein family.width
- 200
- Protein family.Pfam
- PF04272
- Protein family.InterPro
- IPR005984
- Protein family.SCOP
- 1fjk
- Protein family.TCDB
- 1.A.50
- Protein family.OPM family
- 62
- Protein family.OPM protein
- 1zll
- Protein family.Membranome family
- 383
via Wikipedia infobox
Protein · UniProt
Phospholamban
- Gene
- PLN
- Organism
- Homo sapiens (Human)
- Length
- 52 aa
- Molecular mass
- 6,109 Da
- Evidence
- 1: Evidence at protein level
Reversibly inhibits the activity of ATP2A2/SERCA2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+) (PubMed:28890335). Binds preferentially to the ATP-bound E1 conformational form of ATP2A2 which predominates at low Ca(2+) concentrations during the diastolic phase of the cardiac cycle (By similarity). Inhibits ATP2A2 Ca(2+) affinity by disrupting its allosteric activation by ATP (By similarity). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle…
Swiss-Prot (reviewed) · via UniProt
Clinical Trials
3 registered- COMPLETEDIdentification of Disease Specific Pathways and Modifiers in Phospholamban R14del CardiomyopathyUniversity Medical Center Groningen · NCT04978987
- PHASE3COMPLETEDPHOspholamban RElated CArdiomyopathy STudy - InterventionM.p. van den Berg, MD, PhD, professor in Cardiology · NCT01857856
- PHASE1RECRUITINGA Study of AZD4063 in PLN R14del Dilated CardiomyopathyAstraZeneca · NCT07241104
Wikidata facts
- Instance of
- protein
Show 3 more facts
- found in taxon
- Homo sapiens
- exact match
- purl.uniprot.org/uniprot/P26678
- Commons category
- Phospholamban
Sources (3)
via Wikidata · CC0
~2 min read
Encyclopedic overview
6 sectionsContents
- Function
- Clinical significance
- Discovery
- Interactions
- References
- External links
Phospholamban, also known as PLN or PLB, is a micropeptide protein that in humans is encoded by the PLN gene. Phospholamban is a 52-amino acid integral membrane protein that regulates the calcium (Ca2+) pump in cardiac muscle cells.
== Function ==
Excerpted from Wikipedia’s “Phospholamban” article, available under the CC BY-SA 4.0 licence.