Phospholamban

Also known as cardiac phospholamban, PLN

Phospholamban, also known as PLN or PLB, is a micropeptide protein that in humans is encoded by the PLN gene. Phospholamban is a 52-amino acid integral membrane protein that regulates the calcium (Ca2+) pump in cardiac muscle cells.

Key facts

Protein family.caption: Phospholamban pentamer
Protein family.Symbol: Phospholamban
Protein family.image: 1zll_opm.png
Protein family.width: 200
Protein family.Pfam: PF04272
Protein family.InterPro: IPR005984
Protein family.SCOP: 1fjk
Protein family.TCDB: 1.A.50
Protein family.OPM family: 62
Protein family.OPM protein: 1zll
Protein family.Membranome family: 383

via Wikipedia infobox

Protein · UniProt

Phospholamban

Gene: PLN
Organism: Homo sapiens (Human)
Length: 52 aa
Molecular mass: 6,109 Da
Evidence: 1: Evidence at protein level

Reversibly inhibits the activity of ATP2A2/SERCA2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+) (PubMed:28890335). Binds preferentially to the ATP-bound E1 conformational form of ATP2A2 which predominates at low Ca(2+) concentrations during the diastolic phase of the cardiac cycle (By similarity). Inhibits ATP2A2 Ca(2+) affinity by disrupting its allosteric activation by ATP (By similarity). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle…

3D-structureAcetylationCardiomyopathyDisease variantEndoplasmic reticulumLipoproteinMembraneMitochondrion

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Swiss-Prot (reviewed) · via UniProt