SPG21

Also known as ACP33, GL010, MAST, BM-019, spastic paraplegia 21 (autosomal recessive, Mast syndrome), SPG21, maspardin, ABHD21, SPG21 abhydrolase domain containing, maspardin

Maspardin is a protein that in humans is encoded by the SPG21 gene.

Gene data

SPG21

Name: SPG21 abhydrolase domain containing, maspardin
Type: protein-coding
Aliases: ABHD21, ACP33, BM-019, GL010, MAST

The protein encoded by this gene binds to the hydrophobic C-terminal amino acids of CD4 which are involved in repression of T cell activation. The interaction with CD4 is mediated by the noncatalytic alpha/beta hydrolase fold domain of this protein. It is thus proposed that this gene product modulates the stimulatory activity of CD4. Mutations in this gene are associated with autosomal recessive spastic paraplegia 21 (SPG21), also known as mast syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014].

via MyGene.info

Gene · Ensembl

SPG21 abhydrolase domain containing, maspardin

Symbol: SPG21
Biotype: Protein coding
Organism: Homo sapiens
Location: 15:64,954,566-64,990,312
Strand: Reverse (−)
Assembly: GRCh38

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via Ensembl · EMBL-EBI

Wikidata facts

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HomoloGene ID: 9603
exact match: identifiers.org/ncbigene/51324
genomic end: 65282648
genomic start: 64963022
cytogenetic location: 15q22.31

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Maspardin is a protein that in humans is encoded by the SPG21 gene.

The protein encoded by this gene was identified by a two-hybrid screen using CD4 as the bait. It binds to the hydrophobic C-terminal amino acids of CD4 which are involved in repression of T cell activation. The interaction with CD4 is mediated by the noncatalytic alpha/beta hydrolase fold domain of this protein. It is thus proposed that this gene product modulates the stimulatory activity of CD4.