CD4 molecule
Sign in to savethumb|Image of CD4 co-receptor binding to MHC (Major Histocompatibility Complex) non-polymorphic region.
Key facts
- Protein family.Symbol
- CD4-extrcel
- Protein family.Name
- CD4, Cluster of differentiation 4, extracellular
- Protein family.image
- PDB 1wip EBI.jpg
- Protein family.caption
- structure of T cell surface glycoprotein cd4, monoclinic crystal form
- Protein family.Pfam
- PF09191
- Protein family.InterPro
- IPR015274
- Protein family.SCOP
- 1cid
- Protein family.OPM family
- 193
- Protein family.OPM protein
- 2klu
- Protein family.CDD
- cd07695
- Protein family.Membranome family
- 27
via Wikipedia infobox
Article
11 sectionsContents
- Structure
- Function
- Other interactions
- Disease
- HIV infection
- HIV pathology
- Other diseases
- See also
- References
- Further reading
- External links
thumb|Image of CD4 co-receptor binding to MHC (Major Histocompatibility Complex) non-polymorphic region.
In molecular biology, CD4 (cluster of differentiation 4) is a glycoprotein that serves as a co-receptor for the T-cell receptor (TCR). CD4 is found on the surface of immune cells such as helper T cells, monocytes, macrophages, and dendritic cells. It was discovered in the late 1970s and was originally known as leu-3 and T4 (after the OKT4 monoclonal antibody that reacted with it) before being named CD4 in 1984. In humans, the CD4 protein is encoded by the CD4 gene.