CD4 molecule

Also known as CD4 Antigens, T-cell surface antigen T4/Leu-3, CD4 receptor, CD4 antigen (p55), T-cell surface glycoprotein CD4, CD4, CD4 protein

thumb|Image of CD4 co-receptor binding to MHC (Major Histocompatibility Complex) non-polymorphic region.

Key facts

Protein family.Symbol: CD4-extrcel
Protein family.Name: CD4, Cluster of differentiation 4, extracellular
Protein family.image: PDB 1wip EBI.jpg
Protein family.caption: structure of T cell surface glycoprotein cd4, monoclinic crystal form
Protein family.Pfam: PF09191
Protein family.InterPro: IPR015274
Protein family.SCOP: 1cid
Protein family.OPM family: 193
Protein family.OPM protein: 2klu
Protein family.CDD: cd07695
Protein family.Membranome family: 27

via Wikipedia infobox

Protein · UniProt

T-cell surface glycoprotein CD4

Gene: CD4
Organism: Homo sapiens (Human)
Length: 458 aa
Molecular mass: 51,111 Da
Evidence: 1: Evidence at protein level

Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 …

3D-structureAdaptive immunityCell membraneDirect protein sequencingDisulfide bondGlycoproteinHost cell receptor for virus entryHost-virus interaction

View on UniProt →

Swiss-Prot (reviewed) · via UniProt

Clinical Trials

1 registered

PHASE1/PHASE2RECRUITING
CAR-T Cells for HIV InfectionSteven Deeks · NCT04648046

via ClinicalTrials.gov

~7 min read

Encyclopedic overview

11 sections

Contents

Structure
Function
Other interactions
Disease
HIV infection
HIV pathology
Other diseases
See also
References
Further reading
External links

thumb|Image of CD4 co-receptor binding to MHC (Major Histocompatibility Complex) non-polymorphic region.

In molecular biology, CD4 (cluster of differentiation 4) is a glycoprotein that serves as a co-receptor for the T-cell receptor (TCR). CD4 is found on the surface of immune cells such as helper T cells, monocytes, macrophages, and dendritic cells. It was discovered in the late 1970s and was originally known as leu-3 and T4 (after the OKT4 monoclonal antibody that reacted with it) before being named CD4 in 1984. In humans, the CD4 protein is encoded by the CD4 gene.

Excerpted from Wikipedia’s “CD4 molecule” article, available under the CC BY-SA 4.0 licence.