sulfite oxidase
Sign in to saveAlso known as SUOX, sulfite oxidase, mitochondrial, uniprot:P51687
mammalian protein found in Homo sapiens
Protein · UniProt
Sulfite oxidase, mitochondrial
- Gene
- SUOX
- Organism
- Homo sapiens (Human)
- Length
- 545 aa
- Molecular mass
- 60,283 Da
- Evidence
- 1: Evidence at protein level
Catalyzes the oxidation of sulfite to sulfate, the terminal reaction in the oxidative degradation of sulfur-containing amino acids (By similarity). Can run in reverse direction and reduce nitrite to nitric oxide under physiologically relevant conditions, such as hypoxia (PubMed:41337830)
3D-structureDisease variantEpilepsyHemeIntellectual disabilityIronMetal-bindingMitochondrion
View on UniProt →
Swiss-Prot (reviewed) · via UniProt
Research
998 papersvia PubMed
Clinical Trials
4 registered- PHASE1COMPLETEDPhase 1 Single Dose Study of ALXN1101 in Healthy VolunteersOrigin Biosciences · NCT01894165
- PHASE2COMPLETEDSafety & Efficacy Study of ORGN001 (Formerly ALXN1101) in Pediatric Patients With MoCD Type A Currently Treated With rcPMPOrigin Biosciences · NCT02047461
- COMPLETEDA Natural History Study of Molybdenum Cofactor and Isolated Sulfite Oxidase DeficienciesOrigin Biosciences · NCT01735188
- PHASE2/PHASE3COMPLETEDStudy of ORGN001 (Formerly ALXN1101) in Neonates, Infants and Children With Molybdenum Cofactor Deficiency (MOCD) Type AOrigin Biosciences · NCT02629393
Wikidata facts
- Instance of
- protein
Show 4 more facts
- Commons category
- Sulfite oxidase
- cell component
- mitochondrion
- found in taxon
- Homo sapiens
- exact match
- purl.uniprot.org/uniprot/P51687
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