SV40 is an abbreviation for simian vacuolating virus 40 or simian virus 40, a polyomavirus that is found in both monkeys and humans. Like other polyomaviruses, SV40 is a DNA virus that is found to cause tumors in humans and animals, but most often persists as a dormant infection. SV40 has been widely studied as a model eukaryotic virus, leading to many early discoveries in eukaryotic DNA replication and transcription. ==Human disease== The hypothesis that SV40 might cause cancer in humans was a particularly controversial area of research, fuelled by the historical contamination of some batches
SV40 is an abbreviation for simian vacuolating virus 40 or simian virus 40, a polyomavirus that is found in both monkeys and humans. Like other polyomaviruses, SV40 is a DNA virus that is found to cause tumors in humans and animals, but most often persists as a dormant infection. SV40 has been widely studied as a model eukaryotic virus, leading to many early discoveries in eukaryotic DNA replication and transcription. ==Human disease== The hypothesis that SV40 might cause cancer in humans was a particularly controversial area of research, fuelled by the historical contamination of some batches of polio vaccine with SV40 in the 1950s and 1960s. "Persuasive evidence now indicates that SV40 is causing infections in humans today and represents an emerging pathogen." However "It appears unlikely that SV40 infection alone is sufficient to cause human malignancy..."
===p53 damage and carcinogenicity=== It has been suggested that SV40 may act as a co-carcinogen with crocidolite asbestos to cause mesothelioma.
Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).