Also known as entrez:6667, Sp1 transcription factor
protein-coding gene in the species Homo sapiens
Gene data
SP1- Name
- Sp1 transcription factor
- Type
- protein-coding
- Position
- 53,380,176–53,416,446 (+)
- Ensembl
- ENSG00000185591
- RefSeq RNA
- NM_001251825.2, NM_003109.1, NM_138473.3
- RefSeq protein
- NP_001238754.1, NP_003100.1, NP_612482.2
The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. The encoded protein is involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Post-translational modifications such as phosphorylation, acetylation, glycosylation, and proteolytic processing significantly affect the activity of this protein, which can be an activator or a repressor. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Wikidata facts
- Image
- Protein SP1 PDB 1sp1.png
Show 5 more facts
- HomoloGene ID
- 8276
- exact match
- identifiers.org/ncbigene/6667
- genomic end
- 53810230
- genomic start
- 53773960
- cytogenetic location
- 12q13.13
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